Abstract: Ferroptosis is a newly discovered mode of programmed cell death. The main biological features of ferroptosis are the free iron me-diate Fenton reaction, lipid peroxidation of cell membrane lipids, and inhibition of lipid peroxide repair capacity of GPX4. The molecular regulatory mechanisms of ferroptosis are complex, involving multiple biological processes such as iron metabolism, lipid peroxidation reactionsand glutathione metabolism. Ferroptosis is associated with various diseases, including tumors, neurological disorders, ischemia/ reperfusion injury, renal injury, hematological diseases and many other diseases. The use of small-molecule compounds to modulate ferroptosis to inter-vene in the occurrence and development of related diseases has become a hotspot and focus of etiological research and treatment. This paperreviewed the typical features and molecular regulatory mechanisms of ferroptosis, summarized the application of iron death-related small mole-cule compounds, which would provide new reference targets for exploring iron death-related disease research.

Key words: ferroptosis, iron, ROS(Reactive oxygen species), fenton reaction, lipid peroxidation